Search results for " Oral cavity"

showing 8 items of 8 documents

Recent Advances in Drug Delivery from the Oral Cavity. Focus on innovative buccal drug delivery devices

2011

In this report, the drug administration via the oral cavity is discussed. Regional variations in oral mucosae, drug delivery via the keratinised mucosae for local treatment, and drug delivery via the not keratinised mucosae for local and systemic treatments are analyzed, focusing on Buccal drug delivery devices. Finally the IntelliDrug Device is presented as a revolutionary delivery system.

buccal devices oral cavity buccal drug deliverySettore CHIM/09 - Farmaceutico Tecnologico Applicativo
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Biopsy vs. brushing: comparison of two sampling methods for the detection of HPV-DNA in squamous cell carcinoma of the oral cavity

2012

Background: HR HPV infection was proposed as aetiological factor of oral squamous cell carcinomas (OSCC). HPV frequency in OSCC is highly variable, due to the discrepancy in oral sampling procedures, HPV testing methods and inclusion criteria regarding tumour site (strictly oral cavity vs. nearby structures). Our aim was to compare HPV DNA frequency and type-specific distribution in paired cytological and histological samples of SCC strictly located in oral cavity. The correlation between HPV detection rate by each method of sampling and demographical, behavioural and clinical-pathological variables was also examined. Patients and methods: HPV DNA was detected in brushed cells and formalin-…

OncologyAdultMaleCancer Researchmedicine.medical_specialtyPathologySettore MED/07 - Microbiologia E Microbiologia ClinicaConcordanceBiopsyBiologySettore MED/08 - Anatomia PatologicaOral cavitySettore MED/28 - Malattie OdontostomatologicheInternal medicineStatistical significanceGenotypeBiopsymedicineCarcinomaHumansPapillomaviridaeAgedAged 80 and overmedicine.diagnostic_testHPV infectionMiddle Agedmedicine.diseasestomatognathic diseasesHpv testingBiopsy Brushing Human Papilloma Virus (HPV) infection Methods of sampling Oral squamous cell carcinoma (OSCC) Tonsillar squamous cell carcinoma (TSCC) Oropharyngeal squamous cell carcinoma(OPSCC) Head and neck squamous cell carcinoma(HNSCC) Oral cavityOncologyDNA ViralCarcinoma Squamous CellFemaleMouth NeoplasmsOral Surgery
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Adverse drug reactions in the oral cavity

2012

Several drugs may have a number of adverse reactions (ADRs) involving the oro-facial region. The dose of the drug and the time required for the reaction to take place are relevant parameters; nonetheless, ADRs mechanisms are not always known and ADRs are not always predictable since aspects other than drug pharmacodynamics and/or pharmacokinetics, as well as various interacting variables contribute to the final outcome. All tissues and many functions of the oral cavity can be affected. In particular, salivary function is fre- quently involved and hypo-salivation is the main manifestation; several mucosal lesions with different morphology (ulcerations, vesiculo- bullous lesions, white lesion…

Drugdrug pharmacodynamicosteonecrosimedicine.medical_specialtyTime FactorsDrug-Related Side Effects and Adverse Reactionsmedia_common.quotation_subjectSettore MED/50 - Scienze Tecniche Mediche Applicatehypo-salivationPigmentationsPharmacologyOral cavitymucosal lesionDrug withdrawalPharmacokineticsSettore MED/28 - Malattie OdontostomatologicheDrug DiscoveryHumansMedicinemedical liabilityDrug reactionpharmacokineticmedia_commonPharmacologyMouthDose-Response Relationship Drugbusiness.industrybisphosphonates.Mucosal lesionsMouth MucosadrugAdverse reactionmedicine.diseaseDermatologyPharmaceutical PreparationsTastePharmacodynamicsoral cavityadverse drug reaction oral cavityMouth DiseasesSalivationbusiness
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Use of porcine collagen matrix (Mucograft®) to promote the wound healing in the oral cavity

2015

The aim of this study was to evaluate the use of a new collagen matrix (Mucograft®; Geistlich Pharma AG, Wol- husen, Switzerland) in the soft tissue reconstruction after excisional biopsy. The healing of soft tissues after bioptical excision tends to heal by secondary intention. To avoid this, the soft tissue grafts can be harvested from the palate, retromolar pad, or (if available) edentulous site. Disadvantages of harvesting the graft from the retromolar pad and edentulous site are minimal amount of tissue availability and thinner grafts are obtained. The use of collagen matrix is also reported in literature and could represent an optimal solution in the future. Mucograft® is a pure colla…

Settore MED/28 - Malattie Odontostomatologicheporcine collagen matrix wound healing oral cavity graft bioptical excision oral disease
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Oral dysphagia. An unique symptom for a wide spectrum of diseases

2009

Dysphagia, defined as a difficulty in swallowing of fluids and/or solid foods, is one of the most frequent symptoms of esophageal, gastrointestinal, ear, nose and throat diseases. As such, it poses a diagnostic challenge and an interdisciplinary clinical problem. Of particular importance in diagnosis is to distinguish between esophageal and oropharyngeal dysphagia. Oropharyn-geal dysphagia is often associated with neuromuscular disorders and is treated with rehabilitative protocols, while esophageal dysphagia may be due to anatomical alterations and esophageal motility difficulties. While the former can be adequately treated with endoscopic or surgical therapy, the latter are currently trea…

Diagnosis Differentialdysphagia oral cavity systemic diseasesSettore MED/28 - Malattie OdontostomatologichePredictive Value of TestsRisk FactorsPractice Guidelines as TopicHumansDeglutition DisordersDeglutition
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Hemangiopericytoma of the Oral Cavity After a Ten-Year Follow-up

2007

Hemangiopericytoma (HPC) is a mesenchymal tumour that may be benign, malignant, or occur in an intermediate form. We report an unusual case of hemangiopericytoma located in the buccal mucosal region. The histopathologic features showed increased cellularity, necrosis, hemorrhage, low proliferation index, and 4 or less mitotic figures per 10 high-power fields. Since this histological pattern suggests an intermediate form characterized by unpredictable clinical behavior, life-long follow-up is essential. In this patient no recurrences or distant metastases were evident at 10-yr follow-up.

AdultTreatment Outcometumor of oral cavityMouth MucosaHumansFemaleMouth NeoplasmshemangiopericytomaDisease-Free SurvivalFollow-Up Studies
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Bio-pharmaceutics and materials in oral cavity.

2012

Editorial

Settore MED/28 - Malattie OdontostomatologicheBio-pharmaceutics oral cavitySettore MED/50 - Scienze Tecniche Mediche Applicate
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Expression of Remodelling Enzymes (MMP-2, MMP-9) in Normal and Pathological Oral Mucosa Samples

2008

Introduction. The oral cavity contains many structures compressed in a small area. It is exposed to chronic or recurrent, physical and chemical trauma leading to mucosal reactions (e.g. hyperplasia, dysplasia and tumors). For a long time, our group has been studying the expression of some metalloproteinases (MMP-2, MMP-9) in healthy and pathological human oral mucosa through immunohistochemistry and RT-PCR to investigate the entity of the remodelling process in the different cases. Matherials and Methods. In this paper we investigate a sample of normal oral mucosa and four pathological samples (mucocele, fibroma, dysplasia and carcinoma). We identified the localization of MMP-2 and MMP-9 th…

Settore BIO/17 - IstologiaMMP-2 MMP-9 RT-PCR Mucocele Dysplasia Oral cavity
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